Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Deubiquitinases in cancer
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy
Small molecules that directly target MYC and are also well tolerated in vivo will provide
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
[HTML][HTML] CD44+ lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration
Brain metastasis of lung cancer causes high mortality, but the exact mechanisms underlying
the metastasis remain unclear. Here we report that vascular pericytes derived from CD44+ …
the metastasis remain unclear. Here we report that vascular pericytes derived from CD44+ …
Mission possible: advances in MYC therapeutic targeting in cancer
MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …
last several decades, researchers have strived to define the context-dependent …
Deubiquitylating enzymes in cancer and immunity
J Ren, P Yu, S Liu, R Li, X Niu, Y Chen… - Advanced …, 2023 - Wiley Online Library
Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …
CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling
X Zhang, L Chen, W Dang, M Cao, J **ao, S Lv… - Laboratory …, 2020 - nature.com
Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and
facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains …
facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains …
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation
C Ma, D Wang, Z Tian, W Gao, Y Zang, L Qian, X Xu… - Oncogene, 2023 - nature.com
The reversible post-translational modifications of protein ubiquitination and deubiquitination
play a crucial regulatory role in cellular homeostasis. Deubiquitinases (DUBs) are …
play a crucial regulatory role in cellular homeostasis. Deubiquitinases (DUBs) are …
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells
Q Zhu, P Liang, H Meng, F Li, W Miao, C Chu… - Nature …, 2024 - nature.com
The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the
regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated …
regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated …