Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

The origins and importance of spliceosomal introns comprise one of the longest-abiding
mysteries of molecular evolution. Considerable debate remains over several aspects of the …

Alternative splicing creates transcriptome diversification, possibly leading to speciation. A
large fraction of the protein-coding genes of multicellular organisms are alternatively spliced …

Most of the phenotypic diversity that we perceive in the natural world is directly attributable to
the peculiar structure of the eukaryotic gene, which harbors numerous embellishments …

Background Ever since the discovery of'genes in pieces' and mRNA splicing in eukaryotes,
origin and evolution of spliceosomal introns have been considered within the conceptual …

In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …

The availability of multiple, complete eukaryotic genome sequences allows one to address
many fundamental evolutionary questions on genome scale. One such important, long …

The comparative analysis of protein sequences depends crucially on measures of amino
acid similarity or distance. Many such measures exist, yet it is not known how well these …

Numerous previous studies have elucidated 2 surprising patterns of spliceosomal intron
evolution in diverse eukaryotes over the past roughly 100 Myr. First, rates of recent intron …

We study the intron–exon structures of 684 groups of orthologs from seven diverse
eukaryotic genomes and provide maximum likelihood estimates for rates and numbers of …