The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will
often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty …

This review provides a state-of-the-art description of the performance of Sanger cycle
sequencing of the 16S rRNA gene for routine identification of bacteria in the clinical …

Microbiota are thought to influence the development and progression of inflammatory bowel
disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires …

Bacterial culture was the first method used to describe the human microbiota, but this
method is considered outdated by many researchers. Metagenomics studies have since …

The advent of next generation sequencing has coincided with a growth in interest in using
these approaches to better understand the role of the structure and function of the microbial …

The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

The efficacy of cancer immunotherapy largely depends on the tumor microenvironment,
especially the tumor immune microenvironment. Emerging studies have claimed that …

During the past 200 years, our understanding of infectious diseases has radically evolved
from the identification of microbes, to defining their genetic structure, to the development of …

The frequent discrepancy between direct microscopic counts and numbers of culturable
bacteria from environmental samples is just one of several indications that we currently …

This study describes and validates a new method for metagenomic biomarker discovery by
way of class comparison, tests of biological consistency and effect size estimation. This …