The recognition of integrins as a widely expressed family of cell surface adhesion receptors
is around five years old (Hynes, 1987). At that time, one could identify about ten distinct …

THE INTERACTIONS of blood cells with one another, with the vascular endothelium, and
with the subendothelial matrix are essential for a number of physiologic and pathologic …

Occupancy of integrin receptors induces conformational changes in the receptor, resulting in
exposure of novel interactive sites termed ligand-induced binding sites (LIBS). We report …

Much discussion has concerned the central role of ADP in platelet aggregation. We now
describe a patient (ML) with an inherited bleeding disorder whose specific feature is that …

We examined the effects of a stimulatory anti-beta 1 mAb (TS2/16) and different divalent
cations on VLA-4-mediated cell adhesion to vascular cell adhesion molecule-1 (VCAM-1), to …

Integrin adhesion receptors are structurally dynamic proteins that adopt a number of
functionally relevant conformations. We have produced a conformation-dependent anti-α5 …

To analyze the basis of affinity modulation of integrin function, we studied cloned stable
Chinese hamster ovary cell lines expressing recombinant integrins of the beta 3 family …

The human integrin VLA (very late activation antigens)-4 (CD49d/CD29), the leukocyte
receptor for both the CS-1 region of plasma fibronectin (Fn) and the vascular cell surface …

We recently reported the cloning and sequencing of the7 integrin chain and its regulated
expression during the development of skeletal muscle (J. Cell Biol. 117, 643-657). The 7 …

Integrins from the very late activation antigen (VLA) subfamily are involved in cellular
attachment to extracellular matrix (ECM) proteins and in intercellular adhesions. It is known …