PLGA particles in immunotherapy

D Horvath, M Basler - Pharmaceutics, 2023 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) particles are a widely used and extensively studied drug
delivery system. The favorable properties of PLGA such as good bioavailability, controlled …

Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

F Qi, J Wu, H Li, G Ma - Frontiers of Chemical Science and Engineering, 2019 - Springer
Abstract Poly (D, L-lactic-co-glycolic acid)(PLGA)/poly (lactic acid)(PLA) microspheres/
nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic …

Overview on therapeutic applications of microparticulate drug delivery systems

S Bale, A Khurana, ASS Reddy… - Critical reviews™ in …, 2016 - dl.begellhouse.com
Research in novel drug delivery systems is being explored competitively in order to attain
maximum therapeutic effect while minimizing the adverse effects. Despite several …

Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)—Mediated Anti-tumor Therapy

J Koerner, D Horvath, M Groettrup - Frontiers in immunology, 2019 - frontiersin.org
With emerging success in fighting off cancer, chronic infections, and autoimmune diseases,
immunotherapy has become a promising therapeutic approach compared to conventional …

[HTML][HTML] Nano-microparticle platforms in develo** next-generation vaccines

G Cappellano, H Abreu, C Casale, U Dianzani… - Vaccines, 2021 - mdpi.com
The first vaccines ever made were based on live-attenuated or inactivated pathogens, either
whole cells or fragments. Although these vaccines required the co-administration of antigens …

Multiantigenic nanoformulations activate anticancer immunity depending on size

S Li, X Feng, J Wang, W Xu, MA Islam… - Advanced Functional …, 2019 - Wiley Online Library
Nanoparticle‐adjuvanted cancer vaccines are attracting increasing attention because they
can induce an effective anticancer immune response. Single‐antigen vaccines are …

[HTML][HTML] Technological approaches for improving vaccination compliance and coverage

C Lemoine, A Thakur, D Krajišnik, R Guyon, S Longet… - Vaccines, 2020 - mdpi.com
Vaccination has been well recognised as a critically important tool in preventing infectious
disease, yet incomplete immunisation coverage remains a major obstacle to achieving …

Old dog new tricks: PLGA microparticles as an adjuvant for insulin peptide fragment-induced immune tolerance against type 1 diabetes

M Liu, D Feng, X Liang, M Li, J Yang… - Molecular …, 2020 - ACS Publications
Poly [lactic-co-(glycolic acid)](PLGA) is arguably one of the most versatile synthetic
copolymers used for biomedical applications. In vivo delivery of multiple substances …

Overcoming immunogenicity issues of HIV p24 antigen by the use of innovative nanostructured lipid carriers as delivery systems: evidences in mice and non-human …

E Bayon, J Morlieras, N Dereuddre-Bosquet, A Gonon… - Npj Vaccines, 2018 - nature.com
HIV is one of the deadliest pandemics of modern times, having already caused 35 million
deaths around the world. Despite the huge efforts spent to develop treatments, the virus …

Adjuvanticity regulation by biodegradable polymeric nano/microparticle size

J Jia, W Zhang, Q Liu, T Yang, L Wang… - Molecular …, 2017 - ACS Publications
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental
and clinical studies. A more profound understanding of how the physicochemical properties …