Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

To obtain insight into the site and stage specificity of nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), and neurotrophin3(NT-31 action in vivo, we compared …

The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells
has been the subject of numerous studies. Administration of exogenous neurotrophic factors …

Two classes of receptors with distinct affinities for nerve growth factor (NGF) have been
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …

The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine
kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) …

The proto-oncogene Trks encode the high-affinity receptor tyrosine kinases for
neurotrophins of a nerve growth factor (NGF) family. The Trk signals spatiotemporally …

Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune
responses, and inflammation have been identified and characterized at the molecular level …

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be
distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and …

We report the isolation and molecular characterization of t&C, a new member of the trk family
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …