The role of nicotinamide in cancer chemoprevention and therapy
IP Nikas, SA Paschou, HS Ryu - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of
nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism …
nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism …
An updated review on the potential antineoplastic actions of oleuropein
Y Zheng, Z Liu, X Yang, L Liu… - Phytotherapy Research, 2022 - Wiley Online Library
Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It
is a phenolic compound and the most luxuriant in olives. The detailed information related to …
is a phenolic compound and the most luxuriant in olives. The detailed information related to …
[HTML][HTML] Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling
H Liu, N Liu, Y Zhao, X Zhu, C Wang, Q Liu… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
In this study, we investigated the role of ubiquitin-specific protease 22 (USP22) in the growth
and progression of gastric cancer (GC). USP22 mRNA and protein levels were significantly …
and progression of gastric cancer (GC). USP22 mRNA and protein levels were significantly …
[HTML][HTML] HMGB1 promotes prostate cancer development and metastasis by interacting with Brahma-related gene 1 and activating the Akt signaling pathway
DJ Lv, XL Song, B Huang, YZ Yu, FP Shu, C Wang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Abstract Background and Aim: We have previously shown that high-mobility group box 1
(HMGB1) is an independent biomarker for shortened survival of prostate cancer (PCa) …
(HMGB1) is an independent biomarker for shortened survival of prostate cancer (PCa) …
B7‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway
H Liao, M Ding, N Zhou, Y Yang… - Molecular Medicine …, 2022 - spandidos-publications.com
Epithelial‑mesenchymal transition (EMT) is a key step in cancer metastasis. B7‑H3, a co‑
signaling molecule associated with poor prognosis of non‑small cell lung cancer (NSCLC) …
signaling molecule associated with poor prognosis of non‑small cell lung cancer (NSCLC) …
Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
S Zhao, X Zhang, S Chen, S Zhang - Journal of Experimental & Clinical …, 2020 - Springer
Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA
with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to …
with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to …
Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF‐7 breast cancer cells
S Bayat, S Mansoori Derakhshan… - Journal of cellular …, 2019 - Wiley Online Library
Breast cancer is the most common malignancy in the world with the highest rate of morbidity
and mortality. Due to the several side effects of chemotherapy and radiotherapy, recent …
and mortality. Due to the several side effects of chemotherapy and radiotherapy, recent …
Down‐regulation of intracellular anti‐apoptotic proteins, particularly c‐FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL
A Hassanzadeh, M Farshdousti Hagh… - Journal of cellular …, 2018 - Wiley Online Library
Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL or Apo2L) is a member of
the tumor necrosis factor (TNF) superfamily that induces apoptosis in different types of …
the tumor necrosis factor (TNF) superfamily that induces apoptosis in different types of …
Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways
R Wang, S Li, Q Hou, B Zhang, H Chu, Y Hou, C Ni… - Discover Oncology, 2023 - Springer
Background Propofol is a common sedative-hypnotic drug used for general anesthesia.
Recent studies have drawn attention to the antitumor effects of propofol, but the potential …
Recent studies have drawn attention to the antitumor effects of propofol, but the potential …
Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases
N Wössner, Z Alhalabi, J González, S Swyter… - Frontiers in …, 2020 - frontiersin.org
Sirtuin 1 (Sirt1) is a NAD+ dependent lysine deacetylase associated with the pathogenesis
of various diseases including cancer. In many cancer types Sirt1 expression is increased …
of various diseases including cancer. In many cancer types Sirt1 expression is increased …