Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-
translational modifications controlling intracellular signalling events. However, the ubiquitin …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Spinocerebellar ataxia type 3 is a neurodegenerative disorder caused by the expansion of
the polyglutamine repeat region within the ataxin-3 protein. The mutant protein forms …

Polyglutamine (polyQ) diseases are a group of nine neurodegenerative disorders caused by
an unstable CAG expansion in the codifying region of their respective associated genes …

Ubiquitin is attached to a large number of proteins and gives rise to signaling events that
modulate many cellular functions. These signals are often based on the recognition of …

Many pathways important to the nervous system are regulated by the post-translational
conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination …

Evolutionary pressure for protein function leads to unavoidable sampling of conformational
states that are at risk of misfolding and aggregation. The resulting tension between …

Ubiquitination is a key posttranslational modification, which affects numerous biological
processes and is reversed by a class of enzymes known as deubiquitinases (DUBs). This …