A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

Abstract G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich
sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming …

Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

G-Quadruplexes (G4s) are four-stranded nucleic acid structures whose underlying G-rich
sequences are present across the chromosome and transcriptome. These highly structured …

Background The interaction of small molecules with G quadruplexes is in focus due to its
role in molecular recognition and therapeutic drug design. Stabilization of G-quadruplex …

In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused
on the use of nucleobases as synthons in a multicomponent reaction was herein proved to …

Although BRACO19 is a potent G-quadruplex binder, its potential for clinical usage is
hindered by its low selectivity towards DNA G-quadruplex over duplex. High-resolution …

Human telomeric DNA G-quadruplex has been identified as a good therapeutic target in
cancer treatment. G-quadruplex-specific ligands that stabilize the G-quadruplex have great …

In the promoter of c-KIT proto-oncogene, whose deregulation has been implicated in many
cancers, three G-rich regions (kit1, kit* and kit2) are able to fold into G-quadruplexes. While …