000Synthesis of new α-aminophosphonates: Evaluation as anti-inflammatory agents and QSAR studies

I Romero-Estudillo, JL Viveros-Ceballos… - Bioorganic & Medicinal …, 2019 - Elsevier
In this paper, we report the synthesis of a new series of α-aminophosphonates derivatives
based in an efficient three-component reaction. All compounds prepared showed significant …

Carbodiimides in the Synthesis of Enamino‐and α‐Aminophosphonates as Peptidomimetics of Analgesic/Antiinflammatory and Anticancer Agents

WM Abdou, RF Barghash, MS Bekheit - Archiv der Pharmazie, 2012 - Wiley Online Library
Carbodiimide that was generated from the condensation reaction of iminophosphorane with
phenylisocyanate was allowed to react with different phosphorus nucleophiles. Thus, the in …

Synthesis of furo[3,2‐g]chromones under microwave irradiation and their antitumor activity evaluation

SM Abu‐Bakr, MD Khidre, MA Omar… - Journal of …, 2020 - Wiley Online Library
Abstract A series of furo [3, 2‐g] chromone derivatives were synthesized via the reaction of
furochromone carbaldehyde 1 with amines 3a‐d and thioglycolic acid to give …

Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction

E Bálint, A Tripolszky, Á Tajti - 2018 - degruyter.com
α-Aminophosphonates are of significant importance due to their biological activity. The most
widely applied synthetic routes towards α-aminophosphonates are the Kabachnik–Fields …

Antineoplastic activity of fused nitrogen-phosphorus heterocycles and derived phosphonates

WM Abdou, RF Barghash, RE Khidre - Monatshefte für Chemie-Chemical …, 2013 - Springer
A variety of derivatives incorporating substituted heterocycle-phosphor motifs is described.
Substituted N, P-heterocycles and derived phosphonates were produced efficiently in a …

Novel synthesis, docking studies and antitumor evaluation of pyrazolo-and pyrazolo aminophosphonate derivatives derived from N-heterocyclic amines

M Khidre, F Abdelaleem, S Abu Bakr… - Egyptian Journal of …, 2022 - ejchem.journals.ekb.eg
Amino thiophene carbonitrile 1 reacted with chloropyrazole carbaldehyde 2a, b to afford
Schiff bases 3a, b in good yield via condensation reaction. Compounds 3a, b reacted with …

Carbodiimides–key mediators in the synthesis of novel cytotoxic and analgesic/antiinflammatory motifs based on α-amino-, enaminophosphonates, and …

WM Abdou, RF Barghash, MS Bekheit - RSC advances, 2013 - pubs.rsc.org
Based on the prediction results (PASS program), a new series of α-aminophosphonate
derivatives and azaphosphones was synthesized and evaluated as antitumor agents …

[HTML][HTML] Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo [1, 5-b] pyridazines as antinociceptive …

WM Abdou, NA Ganoub… - Beilstein Journal of Organic …, 2013 - beilstein-journals.org
A high-yielding general synthesis of imidazophosphor ester based tetrazolo [1, 5-b]
pyridazines is described. A conjugated reaction between 3, 6-diazidopyridazine and …

Multi-Component Reactions in the Preparation of α-and β-Substituted Phosphonates

MS Bekheit, AA Kamel - Current Organic Chemistry, 2017 - ingentaconnect.com
Multi-component reactions (MCRs) constitute one of the most efficient tools in modern
synthetic organic chemistry used for the preparation of highly functionalized organic …

Niobium pentoxide, a recyclable heterogeneous solid surface catalyst for the synthesis of α-amino phosphonates

A Sahani, RS Rao, A Vadakkayil, M Santhosh… - Journal of Chemical …, 2021 - Springer
Niobium pentoxide, a bifunctional solid surface catalyst, has been successfully employed to
facilitate the three-component reaction between aldehydes, amines and triethyl phosphite at …