Collagen is the most abundant protein in animals. This fibrous, structural protein comprises
a right-handed bundle of three parallel, left-handed polyproline II-type helices. Much …

Collagen-based supplements have become a keystone in the management of the ageing
process, with proven ability to repair skin damage, bestowing a youthful and healthy …

Most abundant in the extracellular matrix are collagens, joined by elastin that confers elastic
recoil to the lung, aorta, and skin. These fibrils are highly resistant to proteolysis but can …

Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by
fragile bones and easy susceptibility to fracture. Most cases of OI are caused by mutations in …

Inspired by self-assembling peptides found in native proteins, deliberately designed
engineered peptides have shown outstanding biocompatibility, biodegradability, and …

The main features of the triple helical structure of collagen were deduced in the mid-1950s
from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average …

Collagen is a major component in a wide range of drug delivery systems and biomaterial
applications. Its basic physical and structural properties, together with its low …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum
(ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

Fibrillar collagens (types I, II, III, V, XI, XXIV and XXVII) constitute a sub-group within the
collagen family (of which there are 28 types in humans) whose functions are to provide three …

Collagen is the major fibrillar protein in most living organisms. Among the different types of
collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to …