Technology is now being developed that is able to handle vast amounts of structured and
unstructured data from diverse sources and origins. These technologies are often referred to …

Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic
representation of critical toxicological effects that propagate over different layers of biological …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …

Based on the results of a Horizon Scanning exercise sponsored by the Society of
Environmental Toxicology and Chemistry that focused on advancing the adverse outcome …

The adverse outcome pathway (AOP) framework serves as a knowledge assembly,
interpretation, and communication tool designed to support the translation of pathway …

Various sources of information can be used to better understand and predict compound
activity and safety-related endpoints, including biological data such as gene expression and …

ABSTRACT In 2007 the United States National Research Council (NRC) published a vision
for toxicity testing in the 21st century that emphasized the use of in vitro high‐throughput …

Background: While establishing efficacy in translational models and humans through
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …

Food safety plays an essential role in our daily lives, and it becomes serious with the
development of worldwide trade. To tackle the food safety issues, many advanced …

The increasing production, use and emission of synthetic chemicals into the environment
represents a major driver of global change. The large number of synthetic chemicals, limited …