Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of
cancer-related death. The high mortality rate results from a lack of methods for early …

Abstract Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can
characterize energy metabolism in the human brain and brain tumors. Here, we present the …

Organic radicals can potentially play important roles in functional materials owing to an
unpaired electron, but they are usually highly reactive and difficult to use. Therefore …

The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be
overcome by hyperpolarization methods, but the most common method (dynamic nuclear …

Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of
MRI, though its ability to inform on relevant changes to biochemistry in humans remains …

Many imaging methods have been proposed to act as surrogate markers of organ damage,
yet for many candidates the essential biomarkers characteristics of the injured organ have …

Applications of NMR for metabolomics and metabolic profiling continue to grow rapidly as
does the refinement of methods for the measurement, analysis, and interpretation of …