Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication.
EVs can be released by every cell type and they can be classified into three major groups …

Most patients are at high risk of thrombosis during cancer treatment. However, the major
discrepancy in the therapeutic mechanisms and microenvironment between tumors and …

Oxidative stress (OS) is a chemical imbalance between an oxidant and an antioxidant,
causing damage to redox signaling and control or causing molecular damage. Unbalanced …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Venous and arterial thromboses, called as cancer-associated thromboembolism (CAT), are
common complications in cancer patients that are associated with high mortality. The cell …

To study how cancer cells can withstand fluid shear stress (SS), we isolated SS-resistant
breast and lung cancer cells using a microfluidic circulatory system. These SS-resistant cells …

Lung cancer is a serious threat to human health with the highest morbidity and mortality;
metastatic lung cancer accounts for a majority of cancer‐related deaths. Hence, there is …

Solid tumor dissemination from the primary site to the sites of metastasis involves tumor cell
transport through the blood or lymph circulation systems. Once the tumor cells enter the …