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Recent progress in non-native nucleic acid modifications
LK McKenzie, R El-Khoury, JD Thorpe… - Chemical Society …, 2021 - pubs.rsc.org
While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
Modified nucleic acids: replication, evolution, and next-generation therapeutics
K Duffy, S Arangundy-Franklin, P Holliger - Bmc Biology, 2020 - Springer
Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages
for biotechnological applications and address some of the limitations of first-generation …
for biotechnological applications and address some of the limitations of first-generation …
What is XNA?
JC Chaput, P Herdewijn - Angewandte Chemie International …, 2019 - Wiley Online Library
What Is XNA? - Chaput - 2019 - Angewandte Chemie International Edition - Wiley Online Library
Skip to Article Content Skip to Article Information Wiley Online Library Wiley Online Library …
Skip to Article Content Skip to Article Information Wiley Online Library Wiley Online Library …
Nucleic acid aptamers: Emerging applications in medical imaging, nanotechnology, neurosciences, and drug delivery
P Röthlisberger, C Gasse, M Hollenstein - International Journal of …, 2017 - mdpi.com
Recent progresses in organic chemistry and molecular biology have allowed the emergence
of numerous new applications of nucleic acids that markedly deviate from their natural …
of numerous new applications of nucleic acids that markedly deviate from their natural …
Unknown unknowns: essential genes in quest for function
The experimental design of a minimal synthetic genome revealed the presence of a large
number of genes without ascribed function, in part because the abstract laws of life must be …
number of genes without ascribed function, in part because the abstract laws of life must be …
Nucleic acid enzymes based on functionalized nucleosides
M Hollenstein - Current Opinion in Chemical Biology, 2019 - Elsevier
Highlights•Nucleic acid-based enzymes are highly potential biosensing and therapeutic
tools.•Description of the chemical methods designed to improve the properties of these …
tools.•Description of the chemical methods designed to improve the properties of these …
Phosphonomethyl oligonucleotides as backbone-modified artificial genetic polymers
C Liu, C Cozens, F Jaziri, J Rozenski… - Journal of the …, 2018 - ACS Publications
Although several synthetic or xenobiotic nucleic acids (XNAs) have been shown to be viable
genetic materials in vitro, major hurdles remain for their in vivo applications, particularly …
genetic materials in vitro, major hurdles remain for their in vivo applications, particularly …
CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
H Yang, E Eremeeva, M Abramov… - Nucleic Acids …, 2023 - academic.oup.com
An enzymatic method has been successfully established enabling the generation of partially
base-modified RNA (previously named RZA) constructs, in which all G residues were …
base-modified RNA (previously named RZA) constructs, in which all G residues were …
Traceless enzymatic synthesis of monodispersed hypermodified oligodeoxyribonucleotide polymers from RNA templates
M Ondruš, V Sýkorová, M Hocek - Chemical Communications, 2022 - pubs.rsc.org
We have developed a new alternative for enzymatic synthesis of single-stranded
hypermodified oligodeoxyribonucleotides displaying four different hydrophobic groups …
hypermodified oligodeoxyribonucleotides displaying four different hydrophobic groups …
Reprint of: non canonical genetic material
E Eremeeva, P Herdewijn - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Xenobiotic Nucleic Acids (XNAs) are highly potential biotechnological and
therapeutic tool.•XNAs possess enhancing thermal and biological stability and increasing …
therapeutic tool.•XNAs possess enhancing thermal and biological stability and increasing …