Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
[HTML][HTML] Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …
transmission efficiency depends on the correct functionality and expression of a plethora of …
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …
which initiates rapid signal transmission in the synapse before its re-uptake into the …
Chronic glutamate toxicity in neurodegenerative diseases—what is the evidence?
J Lewerenz, P Maher - Frontiers in neuroscience, 2015 - frontiersin.org
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
Apoptosis and oxidative stress in neurodegenerative diseases
E Radi, P Formichi, C Battisti… - Journal of Alzheimer's …, 2014 - content.iospress.com
Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …
death. These disorders are characterized by pathological changes in disease-specific areas …
Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
[HTML][HTML] Glutamate, glutamate receptors, and downstream signaling pathways
SS Willard, S Koochekpour - International journal of biological …, 2013 - ncbi.nlm.nih.gov
Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …
De novo mutations in SLC1A2 and CACNA1A are important causes of epileptic encephalopathies
CT Myers, JM McMahon, AL Schneider… - The American Journal of …, 2016 - cell.com
Epileptic encephalopathies (EEs) are the most clinically important group of severe early-
onset epilepsies. Next-generation sequencing has highlighted the crucial contribution of de …
onset epilepsies. Next-generation sequencing has highlighted the crucial contribution of de …