Severe acute respiratory-syndrome coronavirus-2 (SARS-CoV-2) host cell infection is
mediated by binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation …

The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …

Background—Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator
of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the …

Angiotensin-converting enzyme 2 (ACE2) is the first human homologue of ACE to be
described. ACE2 is a type I integral membrane protein that functions as a carboxypeptidase …

Background—The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in
failing human hearts is not well understood. Methods and Results—Angiotensinase activity …

The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

The renin-angiotensin system is a major physiological regulator of arterial pressure and
hydro-electrolyte balance. Evidence has now been accumulated that in addition to …

Peptide hormones such as ANG II and endothelin contribute to cardiac remodeling after
myocardial infarction by stimulating myocyte hypertrophy and myofibroblast proliferation. In …

Background—The renin-angiotensin system (RAS) is a key player in the progression of
heart failure. Angiotensin-(1–7) is thought to modulate the activity of the RAS. Furthermore …