Promises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …
various stimuli and act locally to regulate many aspects of human physiology and disease …
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …
responses. Their function and expression in the tumor microenvironment make them …
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
Interleukin-2 (IL-2) controls the homeostasis and function of regulatory T (Treg) cells, and
defects in the IL-2 pathway contribute to multiple autoimmune diseases. Although …
defects in the IL-2 pathway contribute to multiple autoimmune diseases. Although …
Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
The emerging role of regulatory cell-based therapy in autoimmune disease
F Ghobadinezhad, N Ebrahimi, F Mozaffari… - Frontiers in …, 2022 - frontiersin.org
Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …
millions of people each year and poses a great social and economic burden to individuals …
Electroporation and immunotherapy—unleashing the abscopal effect
Simple Summary Electrochemotherapy and irreversible electroporation are primarily used
for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer …
for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer …
CD8+ T cell exhaustion in anti‐tumour immunity: The new insights for cancer immunotherapy
Y Huang, A Jia, Y Wang, G Liu - Immunology, 2023 - Wiley Online Library
CD8+ T cells play a crucial role in anti‐tumour immunity, but they often undergo exhaustion,
which affects the anti‐tumour activity of CD8+ T cells. The effect and mechanism of …
which affects the anti‐tumour activity of CD8+ T cells. The effect and mechanism of …
Fueling cancer immunotherapy with common gamma chain cytokines
CJ Dwyer, HM Knochelmann, AS Smith… - Frontiers in …, 2019 - frontiersin.org
Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes
redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer …
redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer …
Therapeutic potential of interleukin-15 in cancer
G Isvoranu, M Surcel… - Experimental and …, 2021 - spandidos-publications.com
The immune system is dysfunctional in cancer, and therapeutic approaches designated to
restore immunity and increase long-term overall survival are desirable. The role of …
restore immunity and increase long-term overall survival are desirable. The role of …