Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

The tripartite-motif (TRIM) family of proteins represents one of the largest classes of putative
single protein RING-finger E3 ubiquitin ligases. The members of this family are …

Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Schizophrenia and bipolar disorder are complex psychiatric diseases with risks contributed
by multiple genes. Dysregulation of gene expression has been implicated in these …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …

SUMOylation is a post-translational modification that has emerged in recent decades as a
mechanism involved in controlling diverse physiological processes and that is essential in …

New clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of
tumor suppressors or oncogene products is probably engaged in the etiology of leukemia …

Tripartite motif (TRIM)-containing proteins, one of the largest subfamilies of the RING type E3
ubiquitin ligases, control important biological processes such as cell apoptosis, autophagy …