The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …

Polyploidy (alias whole genome amplification) refers to organisms containing more than two
basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago …

Cancer histological images contain rich biological and clinical information, but quantitative
representation can be problematic and has prevented the direct comparison and …

Inhibition of the mutationally activated Wnt cascade in colorectal cancer cell lines induces a
rapid G 1 arrest and subsequent differentiation. This arrest can be overcome by maintaining …

Polyploid cells demonstrate biological plasticity and stress adaptation in evolution;
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …

MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …

The intestinal epithelium has a remarkable capacity to regenerate after injury and DNA
damage. Here, we show that the integrin effector protein Focal Adhesion Kinase (FAK) is …

The liver has a remarkable capacity to regenerate. Even with surgical removal (partial
hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass …