Molecular docking, DFT and antiproliferative properties of 4‐(3, 4‐dimethoxyphenyl)− 3‐(4‐methoxyphenyl)− 1‐phenyl‐1H‐pyrazolo [3, 4‐b] pyridine as potent …
FA Binjubair, BS Almansour, NI Ziedan… - Drug Development …, 2024 - Wiley Online Library
Due to the limited effeteness and safety concerns associated with current cancer treatments,
there is a pressing need to develop novel therapeutic agents. 4‐(3, 4‐Dimethoxyphenyl)− 3 …
there is a pressing need to develop novel therapeutic agents. 4‐(3, 4‐Dimethoxyphenyl)− 3 …
Development of pyrazolo [1, 5-a] pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer …
This study presents the design, synthesis, and evaluation of a novel series of coumarin-
based compounds (9a-t) as potential anticancer agents. The compounds were strategically …
based compounds (9a-t) as potential anticancer agents. The compounds were strategically …
Novel N-(3-(1-(4-sulfamoylphenyl)triazol-4-yl)phenyl)benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity …
Carbonic anhydrases (CAs) IX and XII are crucial for the survival and metastasis of solid
tumors under hypoxic conditions. We designed compounds 7a–s, integrating triazole and …
tumors under hypoxic conditions. We designed compounds 7a–s, integrating triazole and …
New S-and N-alkyl functionalized bis-1, 2, 4-Triazolyl-based derivatives as potential dual EGFRWT and EGFRT790M inhibitors: Synthesis, anti-proliferative evaluation …
A new series of 2-(s-triazolylsulfanyl) moiety connected with N-arylacetamides 8a-e, 1-aryl
ethanones 10a-c, acetate 12a, acetonitrile 12b, and 2-propane 12c were synthesized via the …
ethanones 10a-c, acetate 12a, acetonitrile 12b, and 2-propane 12c were synthesized via the …