Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Colorectal cancer (CRC) is the second most common cancer in females and the third in
males. Since CRC is often diagnosed at an advanced stage when prognosis is poor …

The WNT signaling pathway has an essential role in colorectal carcinogenesis and
progression, which involves a cascade of genetic and epigenetic changes. We aimed to …

Background Epigenetics refers to the reversible functional modifications of the genome that
do not correlate to changes in the DNA sequence. The aim of this study is to understand …

Gastric cancer (GC) is a common upper gastrointestinal tumor. Death-associated protein
kinase (DAPK1) was found to participate in the development of various malignant tumors …

The aim of the present study was to elucidate the evolutionary trajectory of colon cells from
normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment …

Background Reduced representation bisulfite sequencing (RRBS) was developed to
measure DNA methylation of high-CG regions at single base-pair resolution, and has been …

Reactive astrogliosis is a critical process in neuropathological conditions and neurotrauma.
Although it has been suggested that it confers neuroprotective effects, the exact genomic …

Background Colorectal cancer (CRC) development is accompanied by changes in
expression for several genes; but the details of the underlying regulatory procesess remain …

Background C15orf48 was recently identified as an inflammatory response-related gene;
however there is limited information on its function in tumors. In this study, we aimed to …