Choroid plexus Aquaporins in CSF homeostasis and the Glymphatic system: their relevance for Alzheimer's disease

C Municio, L Carrero, D Antequera, E Carro - International Journal of …, 2023 - mdpi.com
The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is
known to be impaired in neurological disorders, including Alzheimer's disease (AD). For this …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Association between choroid plexus volume and cognition in Parkinson disease

SH Jeong, HJ Jeong, MK Sunwoo… - European Journal of …, 2023 - Wiley Online Library
Background and purpose The choroid plexus (CP) clears harmful metabolites from the
central nervous system as part of the glymphatic system. We investigated the association of …

Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer's continuum

J Jiang, Z Zhuo, A Wang, W Li, S Jiang, Y Duan… - Alzheimer's Research & …, 2024 - Springer
Abstract Background Enlarged choroid plexus (ChP) volume has been reported in patients
with Alzheimer's disease (AD) and inversely correlated with cognitive performance …

[HTML][HTML] Mechanisms of cerebrospinal fluid and brain interstitial fluid production

J **ang, Y Hua, G **, RF Keep - Neurobiology of disease, 2023 - Elsevier
Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus
both being major neurological conditions. Fluid movement from blood into brain is one …

Anti‐seizure medication response and the glymphatic system in patients with focal epilepsy

ST Kim, SE Kim, DA Lee, HJ Lee… - European Journal of …, 2024 - Wiley Online Library
Background and purpose We aimed to evaluate (i) glymphatic system function in patients
with focal epilepsy in comparison with healthy controls, and (ii) the association between anti …

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine

X Sun, B Chen, Y Qi, M Wei, W Chen, X Wu… - The Journal of …, 2024 - Springer
Introduction Migraine, as a complex neurological disease, brings heavy burden to patients
and society. Despite the availability of established therapies, existing medications have …

Cerebrospinal fluid turnover as a driver of brain clearance

NG Smets, GJ Strijkers, V Vinje… - NMR in …, 2024 - Wiley Online Library
Cerebrospinal fluid (CSF) has historically been considered to function as a sink for brain‐
derived waste disposal. Recent work suggested that CSF interacts even more intensely with …

Hypertension: causes and consequences of circadian rhythms in blood pressure

FM Faraci, FAJL Scheer - Circulation Research, 2024 - Am Heart Assoc
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally.
Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and …

Circadian mechanisms in brain fluid biology

VS Vizcarra, RM Fame, LM Hablitz - Circulation Research, 2024 - Am Heart Assoc
The brain is a complex organ, fundamentally changing across the day to perform basic
functions like sleep, thought, and regulating whole-body physiology. This requires a …