Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

Abstract γ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After
nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins …

Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form
protofilaments that associate laterally in varying numbers. It is not known how cellular …

Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-
tubulin complexes, providing spatial and temporal control over the initiation of microtubule …

Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

The γ-tubulin ring complex (γ-TuRC) is a structural template for de novo microtubule
assembly from α/β-tubulin units. The isolated vertebrate γ-TuRC assumes an asymmetric …

The microtubules that comprise mitotic spindles in animal cells are nucleated at
centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin …