Topical drug delivery: History, percutaneous absorption, and product development
Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …
to sophisticated delivery systems. Their development has been facilitated by advances in …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
The important role of stratum corneum lipids for the cutaneous barrier function
J Van Smeden, M Janssens, GS Gooris… - Biochimica et Biophysica …, 2014 - Elsevier
The skin protects the body from unwanted influences from the environment as well as
excessive water loss. The barrier function of the skin is located in the stratum corneum (SC) …
excessive water loss. The barrier function of the skin is located in the stratum corneum (SC) …
Dissecting the formation, structure and barrier function of the stratum corneum
T Matsui, M Amagai - International immunology, 2015 - academic.oup.com
The skin is the largest organ of the mammalian body. The outermost layer of mammalian
skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that …
skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that …
[HTML][HTML] The skin barrier: an extraordinary interface with an exceptional lipid organization
The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …
world and has multiple causes. Over the past decade, data from both experimental models …
[HTML][HTML] The heterogeneity and complexity of skin surface lipids in human skin health and disease
D Mijaljica, JP Townley, F Spada, IP Harrison - Progress in lipid research, 2024 - Elsevier
The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …
Barrier dysfunction in the skin allergy
abstract The skin is continuously exposed to external pathogens, and its barrier function is
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
[HTML][HTML] Chemical penetration enhancers in stratum corneum—Relation between molecular effects and barrier function
Skin is attractive for drug therapy because it offers an easily accessible route without first-
pass metabolism. Transdermal drug delivery is also associated with high patient compliance …
pass metabolism. Transdermal drug delivery is also associated with high patient compliance …
[HTML][HTML] The stratum corneum barrier-from molecular scale to macroscopic properties
The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines
mechanical strength with efficient barrier function. In this paper, we discuss these …
mechanical strength with efficient barrier function. In this paper, we discuss these …