Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?

A Dewitte, S Lepreux, J Villeneuve, C Rigothier… - Annals of intensive …, 2017 - Springer
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Assessing thrombocytopenia in the intensive care unit: the past, present, and future

R Zarychanski, DS Houston - Hematology 2014, the American …, 2017 - ashpublications.org
Thrombocytopenia is common among patients admitted to the intensive care unit (ICU).
Multiple pathophysiological mechanisms may contribute, including thrombin-mediated …

Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

CT Anthon, F Pène, A Perner, E Azoulay, K Puxty… - Intensive care …, 2023 - Springer
Purpose Thrombocytopenia (platelet count< 150× 109/L) is common in intensive care unit
(ICU) patients and is likely associated with worse outcomes. In this study we present …

Is thrombocytopenia an early prognostic marker in septic shock?

N Thiery-Antier, C Binquet, S Vinault… - Critical care …, 2016 - journals.lww.com
Objectives: To assess whether early thrombocytopenia during septic shock is associated
with an increased risk of death at day 28 and to identify risk factors associated with a low …

Risk factors for complications and mortality of percutaneous endoscopic gastrostomy insertion

GY Pih, HK Na, JY Ahn, KW Jung, DH Kim, JH Lee… - BMC …, 2018 - Springer
Background Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure;
however, acute and chronic complications of PEG have been reported. We aimed to …

Platelets and intravascular immunity: guardians of the vascular space during bloodstream infections and sepsis

B McDonald, M Dunbar - Frontiers in immunology, 2019 - frontiersin.org
Despite their humble origins as anuclear fragments of megakaryocytes, platelets have
emerged as versatile mediators of thrombosis and immunity. The diverse spectrum of …

Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries

EM Bordeanu-Diaconescu, A Grosu-Bularda, A Frunza… - Diagnostics, 2024 - mdpi.com
Background and objectives: Burn injuries are the most severe type of trauma, with complex
biological consequences associated with high rates of morbidity and mortality. Prompt …

Thrombocytopenia in intensive care unit patients: a sco** review

AB Jonsson, SL Rygård, T Hildebrandt… - Acta …, 2021 - Wiley Online Library
Background Thrombocytopenia is frequent in intensive care unit (ICU) patients and may be
associated with adverse outcomes. We aimed to assess the incidence, risk factors, and …

Association between platelet levels and 28-day mortality in patients with sepsis: a retrospective analysis of a large clinical database MIMIC-IV

D Wang, S Wang, H Wu, J Gao, K Huang, D Xu… - Frontiers in …, 2022 - frontiersin.org
Background This research focused on evaluating the correlation between platelet count and
sepsis prognosis, and even the dose-response relationship, in a cohort of American adults …

Mechanisms of thrombocytopenia during septic shock: a multiplex cluster analysis of endogenous sepsis mediators

A Bedet, K Razazi, F Boissier, M Surenaud, S Hue… - Shock, 2018 - journals.lww.com
Background: Thrombocytopenia is a common feature of sepsis and may involve various
mechanisms often related to the inflammatory response. This study aimed at evaluating …