Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …

Modern biological research has produced increasing number of promising therapeutic
possibilities for medical treatment. These include for example growth factors, monoclonal …

The objective of this study was to collect a comprehensive database of ocular tissue
permeability measurements found in a review of the literature to guide models for drug …

Topical route of administration is the most commonly used method for the treatment of
ophthalmic diseases. However, presence of several layers of permeation barriers starting …

The presence of tight barriers, which regulate the environment of ocular tissues in the
anterior and posterior part of the eye, is essential for normal visual function. The …

PURPOSE: To characterize quantitatively the paracellular permeation routes in rabbit
cornea, conjunctiva, and sclera using polyethylene glycol (PEG) oligomers. METHODS …

It is generally believed that it is virtually impossible to obtain therapeutic drug concentrations
in the posterior segment of the eye after topical application of aqueous, low viscosity eye …

Despite significant advances in the characterization of tight junction (TJ) proteins, little is
known about how molecular changes relate to function due primarily to the limitations of …

Epithelia and endothelia delineate tissue compartments and control their environments by
regulating the passage of ions and solutes. This barrier function is essential for the …

The paracellular space defines the passive permeation of hydrophilic compounds in
epithelia. The goal of this study was to characterise the paracellular permeation pathway in …