GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …

Through a widespread efferent projection system, the locus coeruleus–noradrenergic
system supplies norepinephrine throughout the central nervous system. Initial studies …

Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …

Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …

In the brain, highly connected and heterogeneous GABAergic cells are crucial in controling
the activity of neuronal networks. They accomplish this task by communicating through …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Despite decades of basic and clinical research, our understanding of how benzodiazepines
tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that …

GABAA (γ-aminobutyric-acid A) and dopamine D1 and D5 receptors represent two
structurally and functionally divergent families of neurotransmitter receptors. The former …

1 Inhibitory postsynaptic currents (IPSCs) evoked in CA1 pyramidal cells (n= 46) by
identified interneurones (n= 43) located in str. oriens were recorded in order to compare …

ABSTRACT Interleukin-1β (IL-1β), a polypeptide immune mediator, is induced within the
central nervous system in response to a variety of pathological stimuli, including systemic …