Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …

Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

E7389, a macrocyclic ketone analog of the marine natural product halichondrin B, currently
is undergoing clinical trials for cancer. This fully synthetic agent exerts its highly potent in …

Type I cells have been defined to be independent of mitochondria for the induction of Fas
death receptormediated apoptosis, whereas Type II cells are mitochondria-dependent …

The extrinsic cell death pathway is initiated upon ligand–receptor interactions at the cell
surface including FAS ligand–FAS/APO1, TNF–TNF receptors, and TRAIL–TRAIL receptors …

Due to the dominating roles that caspases play in the apoptotic cascade, their activities
appear to be a primary factor in the death pathway (apoptosis versus oncosis/necrosis) …

Purpose To assess the safety, pharmacokinetics, and preliminary evidence of antitumor
activity of mapatumumab (HGS-ETR1, TRM-1), a fully human agonist monoclonal antibody …

We have developed an aptameric nanosensor for fluorescence activation imaging of
cytochrome c (Cyt c). Fluorescence imaging tools that enable visualization of key molecular …