New fundamentals in hemostasis
HH Versteeg, JWM Heemskerk, M Levi… - Physiological …, 2013 - journals.physiology.org
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …
Pathogenesis of antiphospholipid syndrome: understanding the antibodies
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …
Lipoprotein receptor signalling in atherosclerosis
C Mineo - Cardiovascular research, 2020 - academic.oup.com
The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …
Activated protein C: biased for translation
The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
Proteases as therapeutics
Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …
Drug Administration) has approved 12 protease therapies, and a number of next generation …
Coagulation and innate immune responses: can we view them separately?
M Delvaeye, EM Conway - Blood, The Journal of the American …, 2009 - ashpublications.org
The horseshoe crab is often referred to as a “living fossil,” representative of the oldest
classes of arthropods, almost identical to species in existence more than 500 million years …
classes of arthropods, almost identical to species in existence more than 500 million years …
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway
EAM Bouwens, F Stavenuiter… - Journal of Thrombosis …, 2013 - Wiley Online Library
The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …
between hemostasis and host defense systems in response to vascular and inflammatory …
Activated protein C, protease activated receptor 1, and neuroprotection
Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
Protease-activated receptor signalling by coagulation proteases in endothelial cells
AR Rezaie - Thrombosis and haemostasis, 2014 - thieme-connect.com
Endothelial cells express several types of integral membrane protein receptors, which upon
interaction and activation by their specific ligands, initiate a signalling network that links …
interaction and activation by their specific ligands, initiate a signalling network that links …
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Inflammation and coagulation are closely linked interdependent processes. Under
physiologic conditions, the tissue microcirculation functions in anticoagulant and anti …
physiologic conditions, the tissue microcirculation functions in anticoagulant and anti …