Multifaceted roles of APOE in Alzheimer disease
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease
Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …
Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
[HTML][HTML] LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease
Y Yang, M García-Cruzado, H Zeng… - Brain, Behavior, and …, 2023 - Elsevier
Microglia have an innate immunity memory (IIM) with divergent functions in different animal
models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
W Zhang, Y Huang, X Guo, M Zhang, X Yuan… - Acta neuropathologica …, 2023 - Springer
Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of
Alzheimer's disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) …
Alzheimer's disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) …
Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol
AG Cashikar, D Toral-Rios, D Timm, J Romero… - Journal of lipid …, 2023 - ASBMB
Neuroinflammation, a major hallmark of Alzheimer's disease and several other neurological
and psychiatric disorders, is often associated with dysregulated cholesterol metabolism …
and psychiatric disorders, is often associated with dysregulated cholesterol metabolism …
Applications of extracellular vesicles in nervous system disorders: an overview of recent advances
Diseases affecting the brain and spinal cord fall under the umbrella term “central nervous
system disease”. Most medications used to treat or prevent chronic diseases of the central …
system disease”. Most medications used to treat or prevent chronic diseases of the central …
[HTML][HTML] The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease
The main role of cholesteryl ester transfer protein (CETP) is the transfer of cholesteryl esters
and triglycerides between high-density lipoprotein (HDL) particles and triglyceride-rich …
and triglycerides between high-density lipoprotein (HDL) particles and triglyceride-rich …
The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides
The toxicology field is concerned with the impact of organophosphorus (OP) compounds on
human health. These compounds have been linked to an increased risk of neurological …
human health. These compounds have been linked to an increased risk of neurological …
Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …