Modulators of Cdc2-like kinases (Clks) and methods of use thereof
J Milne, K Normington, P Puigserver… - US Patent App. 11 …, 2007 - Google Patents
2021-10-27 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Variants derived from ActRIIB
J Knopf, J Seehra, R Kumar - US Patent 9,399,669, 2016 - Google Patents
2008/0261879 A1 10, 2008 Melton et al. US PATENT DOCUMENTS 2009, 0005308 A1
1/2009 Knopfet al. 2009, OO 17019 A1 1/2009 Shields et al. 7,612,041 B2 11/2009 Knopfet …
1/2009 Knopfet al. 2009, OO 17019 A1 1/2009 Shields et al. 7,612,041 B2 11/2009 Knopfet …
Mutations in kit confer Imatinib resistance in gastrointestinal stromal tumors
LL Chen, ML Frazier - US Patent 7,329,495, 2008 - Google Patents
The present invention relates to methods and compositions concerning resistance to a drug
for cancer comprising aber rant KIT signal. Such as aberrant KIT sequence or expres Sion …
for cancer comprising aber rant KIT signal. Such as aberrant KIT sequence or expres Sion …
2-(3-Aminoaryl) amino-4-aryl-thiazoles and Their Use as c-Kit Inhibitors
M Ciufolini, C Wermuth, B Giethlen, A Moussy… - US Patent …, 2013 - Google Patents
The present invention relates to the use of masitinib or a pharmaceutically acceptable salt
thereof, and in particular of masitinib meSylate, for the preparation of a medicament for the …
thereof, and in particular of masitinib meSylate, for the preparation of a medicament for the …
Mass spectrometry assays for identifying compounds that activate deacetylases
J Smith, J Milne, A Lynch, D Carney, A Iffland… - US Patent …, 2012 - Google Patents
Provided are methods for determining the activity of proteins that modulate the acetylation
state of a protein substrate. The methods may be used for determining both …
state of a protein substrate. The methods may be used for determining both …
Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
TF Kowalik, ME Uknis - US Patent 8,361,976, 2013 - Google Patents
2003/01485.19 A1 8/2003 Engelke et al. The present invention, at least in part, relates to the
discovery 2003/0157514 A1 8/2003 Finger et al. of efficacious delivery of an RNAi agent …
discovery 2003/0157514 A1 8/2003 Finger et al. of efficacious delivery of an RNAi agent …
Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity
J Milne, D Carney - US Patent App. 11/885,390, 2008 - Google Patents
Provided are methods for determining the activity of proteins that modulate the acetylation
state of a protein substrate. The methods may be used for determining both …
state of a protein substrate. The methods may be used for determining both …
Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
TF Kowalik, ME Uknis - US Patent 9,150,861, 2015 - Google Patents
The present invention, at least in part, relates to the discovery of efficacious delivery of an
RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue …
RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue …
Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
TF Kowalik, ME Uknis - US Patent 11,220,686, 2022 - Google Patents
The present invention, at least in part, relates to the discov ery of efficacious delivery of an
RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue …
RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue …
Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
TF Kowalik, ME Uknis - US Patent 10,260,066, 2019 - Google Patents
US 2016/0024507 A1 Jan. 28, 2016 Related US Application Data (63) Continuation of
application No. 14/591, 073, filed on Jan. 7, 2015, now Pat. No. 9, 150, 861, which is a …
application No. 14/591, 073, filed on Jan. 7, 2015, now Pat. No. 9, 150, 861, which is a …