Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Peptide materials have a wide array of functions, from tissue engineering and surface
coatings to catalysis and sensing. Tuning the sequence of amino acids that comprise the …

Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …

Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …

Peptides that self-assemble into nanostructures are of tremendous interest for biological,
medical, photonic and nanotechnological applications. The enormous sequence space that …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Coacervates droplets have long been considered as potential protocells to mimic living
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …

The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …

The relative solvent accessibility (RSA) of a residue in a protein measures the extent of
burial or exposure of that residue in the 3D structure. RSA is frequently used to describe a …