Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Biodegradable Mg‐based metals may be promising orthopedic implants for treating
challenging bone diseases, attributed to their desirable mechanical and osteopromotive …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

The sophisticated hierarchical structure that precisely combines contradictory mechanical
and biological characteristics is ideal for biomaterials, but it is challenging to achieve …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

Critical size bone defects are frequently caused by accidental trauma, oncologic surgery,
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …

In the skin, tissue injury results in fibrosis in the form of scars composed of dense
extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound …

Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal
residual disease (MRD) through genetic and nongenetic mechanisms. A key question is …