Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation

Y Ren, H Zhao, C Yin, X Lan, L Wu, X Du… - Frontiers in …, 2022 - frontiersin.org
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Q **ang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation …

FN Varra, M Varras, VK Varra… - Molecular …, 2024 - spandidos-publications.com
Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …

Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish

S Boopathi, B Haridevamuthu, E Mendonca… - Science of the Total …, 2023 - Elsevier
Microplastics (MP), tiny plastic particles, can be ingested by fish through their habitat or
contaminated food sources. When combined with a high-fat diet (HFD), MP exposure may …

NLRP3 inflammasome in hepatic diseases: A pharmacological target

E Ramos-Tovar, P Muriel - Biochemical pharmacology, 2023 - Elsevier
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

Interleukins: pathogenesis in non-alcoholic fatty liver disease

S Rafaqat, S Gluscevic, F Mercantepe, S Rafaqat… - Metabolites, 2024 - mdpi.com
Inflammatory cytokines have been implicated as crucial contributors to the onset and
progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which …

Exploring the multimodal health‐promoting properties of resveratrol: A comprehensive review

Z Faisal, A Mazhar, SA Batool, N Akram… - Food Science & …, 2024 - Wiley Online Library
Resveratrol, a natural polyphenol in various plants, has gained significant attention for its
potential health‐promoting properties. It has been demonstrated, after reviewing various …

[HTML][HTML] The role of gut microbiota and its produced metabolites in obesity, dyslipidemia, adipocyte dysfunction, and its interventions

MSZ Zwartjes, VEA Gerdes, M Nieuwdorp - Metabolites, 2021 - mdpi.com
Obesity is becoming an increasing problem worldwide and is often, but not invariably,
associated with dyslipidemia. The gut microbiota is increasingly linked to cardiovascular …

Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation

M Ghasemzadeh Rahbardar, H Fazeli Kakhki… - Current Nutrition …, 2024 - Springer
Abstract Purpose of Review This review evaluates the therapeutic potential of Ziziphus
jujuba and its main components in managing complications of metabolic syndrome …