Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer
recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion …

Of all the techniques that are currently available to measure binding, isothermal titration
calorimetry is the only one capable of measuring not only the magnitude of the binding …

Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

Intrinsically unstructured proteins (IUPs) are devoid of extensive structural order but often
display signs of local and limited residual structure. To explain their effective functioning, we …

Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to
abnormal accumulation of the key effector β-catenin. Over the past decades, a number of …

Modern techniques in microcalorimetry allow us to measure directly the heat changes and
associated thermodynamics for biomolecular processes in aqueous solution at reasonable …

Human transcriptional regulation factors, such as activators, repressors, and enhancer-
binding factors are quite different from their prokaryotic counterparts in two respects: the …

Protein–protein interactions are thought to be mediated by domains, which are autonomous
folding units of proteins. Recently, a second type of interaction has been suggested …