Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation

S Doktorovova, AB Kovačević, ML Garcia… - European Journal of …, 2016 - Elsevier
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were designed as
exceptionally safe colloidal carriers for the delivery of poorly soluble drugs. SLN/NLC have …

Recent advances in hydrogels as strategy for drug delivery intended to vaginal infections

AM Dos Santos, SG Carvalho, VHS Araujo… - International Journal of …, 2020 - Elsevier
Vaginal infections represent a clear women health problem due to the several issues as
high recurrence rate, drug resistence and emergence of persistent strains. However …

Plants' natural products as alternative promising anti-Candida drugs

S Soliman, D Alnajdy, AA El-Keblawy… - Pharmacognosy …, 2017 - pmc.ncbi.nlm.nih.gov
Candida is a serious life-threatening pathogen, particularly with immunocompromised
patients. Candida infections are considered as a major cause of morbidity and mortality in a …

Nanotechnological strategies for systemic microbial infections treatment: A review

MA dos Santos Ramos, KC Dos Santos… - International Journal of …, 2020 - Elsevier
Systemic infections is one of the major causes of mortality worldwide, and a shortage of drug
approaches applied for the rapid and necessary treatment contribute to increase the levels …

Galleria mellonella for systemic assessment of anti-Candida auris using amphotericin B loaded in nanoemulsion

GD Marena, MADS Ramos, LC Lima, M Chorilli… - Science of The Total …, 2022 - Elsevier
Galleria mellonella is a model that uses adult larvae to assess the prophylactic, therapeutic,
and acute toxic potential of substances. Given their benefits, G. mellonella models are being …

Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida …

BK Harley, AM Quagraine, D Neglo, MO Aggrey… - Plos one, 2022 - journals.plos.org
The antifungal activity of the 70% ethanol stem bark extract of Erythrina senegalensis (ESB)
against different strains and drug resistant clinical isolates of Candida albicans and Candida …

[HTML][HTML] Encephalartos villosus Lem. Displays a Strong In Vivo and In Vitro Antifungal Potential against Candida glabrata Clinical Isolates

MJ Alqahtani, E Elekhnawy, WA Negm, S Mahgoub… - Journal of Fungi, 2022 - mdpi.com
Recently, Candida glabrata has been recognized as one of the most common fungal
species that is highly associated with invasive candidiasis. Its spread could be attributed to …

[HTML][HTML] In vitro and in vivo anti-Helicobacter pylori activity of Casearia sylvestris leaf derivatives

L Spósito, FB Oda, JH Vieira, FA Carvalho… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance The number of bacterial strains that are resistant to
multiple conventional antimicrobial agents is increasing. In this context, natural products …

[HTML][HTML] Improving drug delivery on Candida Albicans using geraniol nanoemulsion

C Silva Pontes, G Garcia de Carvalho… - Pharmaceutics, 2023 - mdpi.com
Geraniol (GE) is a monoterpene alcohol with excellent antifungal activity. However, its low
solubility and high volatility impair its use. Nanoemulsions (NE) are excellent delivery …

Nanoemulsion Increases the Antifungal Activity of Amphotericin B against Four Candida auris Clades: In Vitro and In Vivo Assays

GD Marena, A Ruiz-Gaitán, V Garcia-Bustos… - Microorganisms, 2023 - mdpi.com
Candida auris is an emerging yeast of worldwide interest due to its antifungal resistance and
mortality rates. The aim of this study was to analyse the in vitro and in vivo antifungal activity …