A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19
The global pandemic of Coronavirus Disease 2019 (COVID-19) has brought the world to a
grinding halt. A major cause of concern is the respiratory distress associated mortality …
grinding halt. A major cause of concern is the respiratory distress associated mortality …
Transport, functions, and interaction of calcium and manganese in plant organellar compartments
J He, N Rössner, MTT Hoang, S Alejandro… - Plant …, 2021 - academic.oup.com
Abstract Calcium (Ca2+) and manganese (Mn2+) are essential elements for plants and have
similar ionic radii and binding coordination. They are assigned specific functions within …
similar ionic radii and binding coordination. They are assigned specific functions within …
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function
PPY Lie, L Yoo, CN Goulbourne, MJ Berg… - Science …, 2022 - science.org
Dysfunction and mistrafficking of organelles in autophagy-and endosomal-lysosomal
pathways are implicated in neurodegenerative diseases. Here, we reveal selective …
pathways are implicated in neurodegenerative diseases. Here, we reveal selective …
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors
A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2024 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
Determinants of phagosomal pH during host-pathogen interactions
The ability of phagosomes to halt microbial growth is intimately linked to their ability to
acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise …
acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise …
Multiple SARS-CoV-2 variants exhibit variable target cell infectivity and ability to evade antibody neutralization
H Tang, L Gao, Z Wu, F Meng, X Zhao, Y Shao… - Frontiers in …, 2022 - frontiersin.org
The continuous emergence of SARS-coronavirus 2 (SARS-CoV-2) variants, especially the
variants of concern (VOC), exacerbated the impact of the coronavirus disease 2019 (COVID …
variants of concern (VOC), exacerbated the impact of the coronavirus disease 2019 (COVID …
Activation of endo-lysosomal two-pore channels by NAADP and PI (3, 5) P2. Five things to know.
Two-pore channels are ancient members of the voltage-gated ion channel superfamily that
are expressed predominantly on acidic organelles such as endosomes and lysosomes …
are expressed predominantly on acidic organelles such as endosomes and lysosomes …
Tamoxifen Activates Transcription Factor EB and Triggers Protective Autophagy in Breast Cancer Cells by Inducing Lysosomal Calcium Release: A Gateway to the …
Among the several mechanisms accounting for endocrine resistance in breast cancer,
autophagy has emerged as an important player. Previous reports have evidenced that …
autophagy has emerged as an important player. Previous reports have evidenced that …
[HTML][HTML] Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation
Two pore channels (TPCs) and mucolipins (TRPML) are the most prominent cation channels
expressed in endolysosomes. Recently, roles of TPCs and TRPML2 have been revealed in …
expressed in endolysosomes. Recently, roles of TPCs and TRPML2 have been revealed in …
Endolysosomal Ca2+ signaling in cardiovascular health and disease
An increase in intracellular Ca 2+ concentration ([Ca 2+] i) regulates a plethora of functions
in the cardiovascular (CV) system, including contraction in cardiomyocytes and vascular …
in the cardiovascular (CV) system, including contraction in cardiomyocytes and vascular …