Therapeutic targeting of 3′, 5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
GS Baillie, GS Tejeda, MP Kelly - Nature reviews Drug discovery, 2019 - nature.com
Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …
pursued as therapeutic targets for several diseases, including those affecting the nervous …
Future targets for migraine treatment beyond CGRP
Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …
Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans
TP Do, C Deligianni, S Amirguliyev, J Snellman… - Brain, 2023 - academic.oup.com
There are several endogenous molecules that can trigger migraine attacks when
administered to humans. Notably, calcitonin gene-related peptide (CGRP) has been …
administered to humans. Notably, calcitonin gene-related peptide (CGRP) has been …
Migraine induction with calcitonin gene-related peptide in patients from erenumab trials
Background Migraine prevention with erenumab and migraine induction by calcitonin gene-
related peptide (CGRP) both carry notable individual variance. We wanted to explore a …
related peptide (CGRP) both carry notable individual variance. We wanted to explore a …
Early treatment with sumatriptan prevents PACAP38-induced migraine: A randomised clinical trial
Objective To determine whether early treatment with sumatriptan can prevent PACAP38-
induced migraine attacks. Methods A total of 37 patients with migraine without aura were …
induced migraine attacks. Methods A total of 37 patients with migraine without aura were …
CGRP in human models of migraine
Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …
Future prophylactic treatments in migraine: beyond anti-CGRP monoclonal antibodies and gepants
Migraine is ranked as a leading cause of years lived with disability among all neurological
disorders. Therapies targeting the calcitonin gene-related peptide (CGRP) signaling …
disorders. Therapies targeting the calcitonin gene-related peptide (CGRP) signaling …
Association between sumatriptan treatment during a migraine attack and central 5-HT1B receptor binding
Importance Triptans, the most efficient acute treatment for migraine attacks, are 5-HT 1B/1D
receptor agonists, but their precise mechanism of action is not completely understood. The …
receptor agonists, but their precise mechanism of action is not completely understood. The …
Pituitary adenylate cyclase‐activating polypeptide receptors in the trigeminovascular system: implications for migraine
T Sundrum, CS Walker - British journal of pharmacology, 2018 - Wiley Online Library
The neuropeptide pituitary adenylate cyclase‐activating polypeptide (PACAP) has been
implicated in a wide range of functions including vasodilatation, neuroprotection …
implicated in a wide range of functions including vasodilatation, neuroprotection …
Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling
Abstract Background Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the
neurobiologic underpinnings of migraine. Considering the clinical similarities between …
neurobiologic underpinnings of migraine. Considering the clinical similarities between …