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Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …
nervous system. During fetal development, the initial colonization of the microbiome …
Towards an immunophenotype of schizophrenia: progress, potential mechanisms, and future directions
The evidence to date, coupled with advances in immunology and genetics has afforded the
field an unparalleled opportunity to investigate the hypothesis that a subset of patients with …
field an unparalleled opportunity to investigate the hypothesis that a subset of patients with …
[HTML][HTML] Immune-inflammatory markers and psychosis risk: A systematic review and meta-analysis
Subclinical inflammation has been associated with psychosis; however, it remains unknown
whether this phenomenon appears also in the premorbid phase. Therefore, we performed a …
whether this phenomenon appears also in the premorbid phase. Therefore, we performed a …
The role of aberrations in the immune-inflammatory response system (IRS) and the compensatory immune-regulatory reflex system (CIRS) in different phenotypes of …
Several lines of evidence indicate that aberrations in immune-inflammatory pathways may
contribute to the pathophysiology of schizophrenia spectrum disorders. Here, we propose a …
contribute to the pathophysiology of schizophrenia spectrum disorders. Here, we propose a …
Constructing the immune signature of schizophrenia for clinical use and research; an integrative review translating descriptives into diagnostics
Schizophrenia is considered a syndrome comprised by several disease phenotypes,
covering a range of underlying pathologies. One of these disease mechanisms seems to …
covering a range of underlying pathologies. One of these disease mechanisms seems to …
Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk
Immunological/inflammatory factors are implicated in the development of psychosis.
Complement is a key driver of inflammation; however, it remains unknown which factor is …
Complement is a key driver of inflammation; however, it remains unknown which factor is …
Redox and immune signaling in schizophrenia: new therapeutic potential
Redox biology and immune signaling play major roles in the body, including in brain
function. A rapidly growing literature also suggests that redox and immune abnormalities are …
function. A rapidly growing literature also suggests that redox and immune abnormalities are …
Changes in inflammatory balance correlates with conversion to psychosis among individuals at clinical high-risk: a prospective cohort study
Previous studies have revealed that the imbalance between Th1 cytokines and Th2
cytokines plays a role in disturbance of cellular responses in the brain during psychosis …
cytokines plays a role in disturbance of cellular responses in the brain during psychosis …
[HTML][HTML] Inflammatory biomarkers in schizophrenia: Implications for heterogeneity and neurobiology
The longstanding investigation of immune system abnormalities, including inflammation, in
schizophrenia has tremendous renewed interest as an area of research. Presently, the field …
schizophrenia has tremendous renewed interest as an area of research. Presently, the field …
[HTML][HTML] Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Background Immune dysregulation has been observed in patients with schizophrenia or first-
episode psychosis, but few have examined dysregulation in those at clinical high-risk (CHR) …
episode psychosis, but few have examined dysregulation in those at clinical high-risk (CHR) …