Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–
cell interactions in processes as diverse as tissue development, immune cell trafficking and …

The ability to design functional sequences and predict effects of variation is central to protein
engineering and biotherapeutics. State-of-art computational methods rely on models that …

The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a
biomanufacturing platform has been limited by a lack of genetic tools. Here we report …

Polar auxin transport is unique to plants and coordinates their growth and development,.
The PIN-FORMED (PIN) auxin transporters exhibit highly asymmetrical localizations at the …

Abstract γ-Aminobutyric acid (GABA) transporter 1 (GAT1) regulates neuronal excitation of
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …

Abstract SARS-CoV-2, the causative agent of COVID-19, features a receptor-binding domain
(RBD) for binding to the host cell ACE2 protein,,,,–. Neutralizing antibodies that block RBD …

Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in
action,–. ATP-binding cassette (ABC) exporters are highly dynamic membrane proteins that …

We describe a general method that allows structure determination of small proteins by single-
particle cryo-electron microscopy (cryo-EM). The method is based on the availability of a …