GABAA receptors mediate fast synaptic inhibitory neurotransmission throughout the central
nervous system. Recent work indicates a role for GABAA receptors in physiologically …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …

An animal model of human behavior represents a complex of cognitive and/or emotional
processess, which are translated from animals to humans. A behavioral test is developed …

Stress exposure activates the autonomic nervous system and leads to a body temperature
increase (stress-induced hyperthermia, SIH). On the other hand, an activation of the immune …

There is ample evidence that genetic factors play an important role in anxiety disorders. In
support, human genome-wide association studies have implicated several novel candidate …

Background Within the GABAA-receptor field, two important questions are what molecular
mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to …

Rationale Zolpidem is a positive allosteric modulator of γ-aminobutyric acid (GABA) with
preferential binding affinity and efficacy for α1-subunit containing GABA A receptors (α1 …

OBJECTIVES: There are several models of depression. Chronic unpredictable mild stress
(CMS) appears to have the greatest validity, although it is often being criticized for low …

The putative endogenous imidazoline binding site ligand harmane enhances neuronal
activation in response to psychological stress and alters behaviour in animal models of …

Therapy of seizure activity following exposure to the nerve agent soman (GD) includes
treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric …