State-dependent effects of neural stimulation on brain function and cognition

C Bradley, AS Nydam, PE Dux… - Nature Reviews …, 2022 - nature.com
Invasive and non-invasive brain stimulation methods are widely used in neuroscience to
establish causal relationships between distinct brain regions and the sensory, cognitive and …

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Centering cognitive neuroscience on task demands and generalization

M Nau, AC Schmid, SM Kaplan, CI Baker… - Nature …, 2024 - nature.com
Cognitive neuroscience seeks generalizable theories explaining the relationship between
behavioral, physiological and mental states. In pursuit of such theories, we propose a …

The prefrontal cortex, pathological anxiety, and anxiety disorders

MM Kenwood, NH Kalin, H Barbas - Neuropsychopharmacology, 2022 - nature.com
Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

Ultrasound technologies for imaging and modulating neural activity

C Rabut, S Yoo, RC Hurt, Z **, H Li, H Guo, B Ling… - Neuron, 2020 - cell.com
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans

SN Yaakub, TA White, J Roberts, E Martin… - Nature …, 2023 - nature.com
Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive
technique for focally modulating human brain function. The mechanisms and neurochemical …

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

S Yoo, DR Mittelstein, RC Hurt, J Lacroix… - Nature …, 2022 - nature.com
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …

Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation

K Yu, X Niu, E Krook-Magnuson, B He - Nature communications, 2021 - nature.com
Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its
mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct …

Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function

DG Blackmore, D Razansky, J Götz - Neuron, 2023 - cell.com
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …