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Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
L Merkens, V Sailer, D Lessel, E Janzen… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
PARP1 at the crossroad of cellular senescence and nucleolar processes
K Kołacz, A Robaszkiewicz - Ageing research reviews, 2024 - Elsevier
Senescent cells that occur in response to telomere shortening, oncogenes, extracellular and
intracellular stress factors are characterized by permanent cell cycle arrest, the …
intracellular stress factors are characterized by permanent cell cycle arrest, the …
EZH2 directly methylates PARP1 and regulates its activity in cancer
DNA repair dysregulation is a key driver of cancer development. Understanding the
molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for …
molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for …
PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis
Y Qin, X Dong, M Lu, L **g, Q Chen, F Guan, Z **es the heart repair process, eventually leading to heart failure. This …
A new opportunity for “old” molecules: targeting PARP1 activity through a non-enzymatic mechanism
P Iglesias, M Seoane, I Golán-Cancela… - International Journal of …, 2023 - mdpi.com
In recent years, new therapies have been developed based on molecules that target
molecular mechanisms involved in both the initiation and maintenance of the oncogenic …
molecular mechanisms involved in both the initiation and maintenance of the oncogenic …
PARP1: Opportunities of Develo** New Drugs for an Old Target
VM Arce, P Iglesias, JA Costoya - 2024 - Springer
The poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) family of proteins
includes 17 members in mammals, most of which are enzymes that are responsible for …
includes 17 members in mammals, most of which are enzymes that are responsible for …
[PDF][PDF] PARP1: New Drug Development Opportunities for an Old Target
P Iglesias, M Seoane, I Golán-Cancela, M Fraga… - 2023 - preprints.org
In recent years, new therapies have been developed based on molecules that target
molecular mechanisms involved in both the initiation and maintenance of the oncogenic …
molecular mechanisms involved in both the initiation and maintenance of the oncogenic …