Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides
as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on …

The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but
also in sensing internal molecules that may constitute signals of cellular dysfunction. It …

Neutrophils must follow both endogenous and bacterial chemoattractant signals out of the
vasculature and through the interstitium to arrive at a site of infection. By necessity, in the …

Since their discovery 13 years ago, chemokines have emerged as the most important
regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

Since we live in a dirty environment, we have developed many host defenses to contend
with microorganisms. The epithelial lining of our skin, gastrointestinal tract and bronchial …

FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant
receptor superfamily. Because of their capacity to interact with bacterial chemotactic …

Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of
a gradient of locally produced chemotactic factors. This review is focused on current …

Cross-desensitization between μ-opioid receptor agonists and CC chemokines was shown
to occur in immune cells and in the central nervous system. However, these cells do not …