Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …

A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

The composition and identity of cell organelles are dictated by the flux of lipids and proteins
that they receive and lose through cytosolic exchange and membrane trafficking. The trans …

The epidermis and in particular its outermost layer the stratum corneum provides terrestrial
vertebrates with a pivotal defensive barrier against water loss, xenobiotics and harmful …

Mitochondria are partially autonomous organelles that depend on the import of certain
proteins and lipids to maintain cell survival and membrane formation. Although …

Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and
neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and …

Sphingolipids (SLs) have been considered for many years as predominant building blocks
of biological membranes with key structural functions and little relevance in cellular …

β-Glucosidase 2 (GBA2) is a resident enzyme of the endoplasmic reticulum thought to play a
role in the metabolism of bile acid–glucose conjugates. To gain insight into the biological …

Sphingomyelin (SM) and cholesterol are coregulated metabolically and associate physically
in membrane microdomains involved in cargo sorting and signaling. One mechanism for …