Oral and maxillofacial diseases such as infection and trauma often involve various organs
and tissues, resulting in structural defects, dysfunctions and/or adverse effects on facial …

Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …

Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …

Sjogren's syndrome and radiotherapy for head and neck cancers result in irreversible
damage to functional salivary tissue, for which no adequate treatment is available. The …

Background Breast cancer cells invading the connective tissues outside the mammary
lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and …

Stem cell therapies are promising strategies to regenerate human injured tissues, including
ischemic myocardium. Here, we examined the acquisition of properties associated with …

The salivary gland is a complex, secretory tissue that produces saliva and maintains oral
homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or …

Abstract Development of a tissue-engineered, salivary bio-gland will benefit patients
suffering from xerostomia due to loss of fluid-secreting acinar cells. This study was …

A few treatment options exist for patients experiencing xerostomia due to hyposalivation that
occurs as a result of disease or injury to the gland. An opportunity for a permanent solution …

Progress in the development of salivary gland regenerative strategies is limited by poor
maintenance of the secretory function of salivary gland cells (SGCs) in vitro. To reduce the …