Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and
involution to prepare the gland for subsequent lactation. The mammary epithelial cells …

Basal breast cancer is associated with younger age, early relapse, and a high mortality rate.
Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate …

Studies over the past decades have implicated lncRNAs in promoting the development,
migration and invasion of gastric cancer (GC). However, the role and mechanism of lncRNA …

In rodents, weaning-induced mammary gland involution supports increased mammary tumor
incidence, growth, and progression to metastasis. Further, the protumor attributes of gland …

Breast cancer is the second leading cause of death among women worldwide, and while
hormone receptor positive subtypes have a clear and effective treatment strategy, other …

The P2X7 receptor is an ATP-gated cation channel with a still ambiguous role in cancer
progression, proposed to be either pro-or anti-cancerous, depending on the cancer or cell …

Mammographically-detected breast density impacts breast cancer risk and progression, and
fibrillar collagen is a key component of breast density. However, physiologic factors …

Background A large collaborative analysis of data from 47 epidemiological studies
concluded that longer duration of breastfeeding reduces the risk of develo** breast …

Postpartum involution is the process by which the lactating mammary gland returns to the
pre-pregnant state after weaning. Expression of tumor-promotional collagen, upregulation of …