Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how
cancer cells may die or resist cancer drugs is critical to providing certain strategies to …

Breast cancer is a heterogeneous disease that encompasses several distinct entities with
remarkably different biological characteristics and clinical behaviour. Currently, breast …

Triple-negative breast cancer (TNBC) is defined by a lack of expression of both estrogen
and progesterone receptor as well as human epidermal growth factor receptor 2. It is …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

The exact functions of BRCA1 have not been fully described but it now seems apparent that
it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most …

Signalling pathway activation analysis is a powerful approach for extracting biologically
relevant features from large-scale transcriptomic and proteomic data. However, modern …

Learning Objectives After completing this course, the reader will be able to: List the
biomarkers that are currently used and those that may be of potential use in the …

Since cancer is one of the leading causes of death worldwide, there is an urgent need to find
better treatments. Currently, the use of chemotherapeutics remains the predominant option …

BRCA1 germline mutations predispose women to early onset, familial breast and
ovariancancer. BRCA1 has been recently implicated in the cellular response to agents that …