Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential–a review

TU Jayawardena, N Merindol, NS Liyanage… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2017 to 2023 (now) Amaryllidaceae alkaloids (AAs) are a unique class of
specialized metabolites containing heterocyclic nitrogen bridging that play a distinct role in …

Navigating Amaryllidaceae alkaloids: bridging gaps and charting biosynthetic territories

NS Liyanage, F Awwad… - Journal of …, 2025 - academic.oup.com
Amaryllidaceae alkaloid (AA) biosynthesis has garnered significant attention in recent years,
particularly with the commercialization of galanthamine as a treatment for the symptoms of …

Amaryllidaceae alkaloid cherylline inhibits the replication of dengue and Zika viruses

S Ka, N Merindol, AA Sow, A Singh… - Antimicrobial Agents …, 2021 - journals.asm.org
Dengue fever, caused by dengue virus (DENV), is the most prevalent arthropod-borne viral
disease and is endemic in many tropical and subtropical parts of the world, with an …

Endophytic bacteria from in vitro culture of Leucojum aestivum L. a new source of galanthamine and elicitor of alkaloid biosynthesis

A Ptak, E Morańska, M Warchoł, A Gurgul… - Scientific Reports, 2022 - nature.com
Leucojum aestivum is known for its ability to biosynthesize alkaloids with therapeutic
properties, among which galanthamine used for the treatment of Alzheimer's disease. New …

[HTML][HTML] Chemical synthesis and biological activities of Amaryllidaceae alkaloid norbelladine derivatives and precursors

MP Girard, V Karimzadegan, M Héneault, F Cloutier… - Molecules, 2022 - mdpi.com
Amaryllidaceae alkaloids (AAs) are a structurally diverse family of alkaloids recognized for
their many therapeutic properties, such as antiviral, anti-cholinesterase, and anticancer …

Elusive partners: a review of the auxiliary proteins guiding metabolic flux in flavonoid biosynthesis

M Dastmalchi - The Plant Journal, 2021 - Wiley Online Library
Flavonoids are specialized metabolites widely distributed across the plant kingdom. They
are involved in the growth and survival of plants, conferring the ability to filter ultra‐violet …

Transcriptome analysis of Leucojum aestivum and identification of genes involved in norbelladine biosynthesis

L Tousignant, AM Diaz-Garza, BB Majhi, SE Gélinas… - Planta, 2022 - Springer
Main conclusion Transcriptome analysis of Leucojum aestivum led to the identification of 50
key genes associated with Amaryllidaceae alkaloid biosynthesis including norbelladine …

Kinetic and in silico structural characterization of norbelladine O-methyltransferase of Amaryllidaceae alkaloids biosynthesis

M Koirala, N Merindol, V Karimzadegan… - Journal of Biological …, 2024 - jbc.org
Amaryllidaceae alkaloids are a diverse group of alkaloids exclusively reported from the
Amaryllidaceae plant family. In planta, their biosynthesis is still not fully characterized; …

[HTML][HTML] Biotechnological approaches to optimize the production of Amaryllidaceae alkaloids

M Koirala, V Karimzadegan, NS Liyanage, N Mérindol… - Biomolecules, 2022 - mdpi.com
Amaryllidaceae alkaloids (AAs) are plant specialized metabolites with therapeutic properties
exclusively produced by the Amaryllidaceae plant family. The two most studied …

Harnessing plant biotechnology-based strategies for in vitro galanthamine (GAL) biosynthesis: A potent drug against Alzheimer's disease

H Kaur, S Chahal, P Jha, MM Lekhak… - Plant Cell, Tissue and …, 2022 - Springer
Medicinal plants are important for improving human health and represent an essential pool
for the identification of novel pharmacological leads. Plant-derived biomolecules have …